A new web hub focussed on providing gastroenterologists with the latest information on the diagnosis, treatment and management of patients with gut related disorders.
Kurien M et al. Frontline Gastroenterology 2018;9:92–97.
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Dr. Fermín Mearin-Manrique
Symptoms in this patient point towards a diagnosis of irritable bowel syndrome (IBS)
Inﬂammatory bowel disease: clinical aspects and treatments
Fakhoury M et al. J Inflamm Res 2014;7:113–120.
High prevalence of idiopathic bile acid diarrhoea among patients with diarrhoea-predominant irritable bowel syndrome based on Rome III criteria
Aziz, I, Mumtaz S, Bholah H et al. Clin Gastroenterol Hepatol 2015;13:1650–1655.
Bile acid disease: the emerging epidemic
Oduyebo I & Camilleri M. Curr Opin Gastroenterol 2017;33:189–195.
Physiology of bile acid diarrhoea
Bile acid diarrhoea (BAD) is a common but under-recognised cause of chronic functional diarrhoea, accounting for up to a third of patients who otherwise would be labelled as diarrhoea-predominant irritable bowel syndrome (IBS-D).
Prevalence of irritable bowel syndrome–type symptoms in patients with celiac disease: a meta-analysis
Sainsbury A, Sanders D & Ford A. Clin Gastroenterol Hepatol 2013;11:359–365.
Management of bile acid malabsorption using low-fat dietary interventions: a useful strategy applicable to some patients with diarrhoea-predominant irritable bowel syndrome?
Watson L et al. Clin Med (Lond) 2015;15:536–540.
Professor Julian R.F. Walters
Are the current treatments for bile acid diarrhoea effective (BAD), and is it likely that in the future there will be better treatments for BAD?
Current therapies, such as colestyramine and colesevelam, bind and eliminate bile acids from the colon. These drugs prevent the excess bile acids causing watery faeces.
Is bile acid diarrhoea underdiagnosed in patients with Crohn’s disease?
Definitely, yes. Unfortunately for patients with Crohn’s disease, there is a poor relationship between their symptoms and intestinal inflammation, and a considerable proportion of patients’ present symptoms that are not due to the inflammation but rather to bile acid diarrhoea.
Professor David S. Sanders
What is the overall benefit for clinicians of an early diagnosis of bile acid diarrhoea?
The benefit is quite significant, both for the physician and for the patient. For physicians, it provides the possibility to avoid numerous diagnostic tests.
For example, when investigating patients with unselected irritable bowel syndrome-type symptoms the chances of successfully diagnosing a disease through colonoscopy are very low..
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