Current therapies, such as colestyramine and colesevelam, bind and eliminate bile acids from the colon. These drugs prevent the excess bile acids causing watery faeces.
Is bile acid diarrhoea underdiagnosed in patients with Crohn’s disease?
Definitely, yes. Unfortunately for patients with Crohn’s disease, there is a poor relationship between their symptoms and intestinal inflammation, and a considerable proportion of patients’ present symptoms that are not due to the inflammation but rather to bile acid diarrhoea.
What is the overall benefit for clinicians of an early diagnosis of bile acid diarrhoea?
The benefit is quite significant, both for the physician and for the patient. For physicians, it provides the possibility to avoid numerous diagnostic tests.
MARCH 2020
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