A source for healthcare professionals to access the latest data and information on the diagnosis, treatment and management of patients with gut related disorders


Expert opinion

Dr Fermín Mearin-Manrique

Director of the Department of Gastroenterology, Institute of Functional and Motor Digestive Disorders, Barcelona, Spain

What is the role of bile acid malabsorption in diarrhoea-predominant irritable bowel syndrome?


In diarrhoea-predominant irritable bowel syndrome, it has been shown that up to 40% of patients are affected by some type of bile acid metabolism disorder, either as malabsorption or with increased bile acid synthesis, reaching in this case percentages of up to 30%. Therefore, it is important to determine the presence of this disorder, given that it affects a patient group that presents with diarrhoea, although on other occasions the symptoms alternate between diarrhoea and constipation.

Considerable improvement can be achieved through treatment with bile acid sequestrants. An accurate diagnosis of this disease in this patient subgroup is therefore very important.

Job number: JB57410GBj Date of Preparation: June 2019

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