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A source for healthcare professionals to access the latest data and information on the diagnosis, treatment and management of patients with gut related disorders
Dr Fermín Mearin-Manrique
Director of the Department of Gastroenterology, Institute of Functional and Motor Digestive Disorders, Barcelona, Spain
What is the role of bile acid malabsorption in diarrhoea-predominant irritable bowel syndrome?
In diarrhoea-predominant irritable bowel syndrome, it has been shown that up to 40% of patients are affected by some type of bile acid metabolism disorder, either as malabsorption or with increased bile acid synthesis, reaching in this case percentages of up to 30%. Therefore, it is important to determine the presence of this disorder, given that it affects a patient group that presents with diarrhoea, although on other occasions the symptoms alternate between diarrhoea and constipation.
Considerable improvement can be achieved through treatment with bile acid sequestrants. An accurate diagnosis of this disease in this patient subgroup is therefore very important.
Job number: JB57410GBj Date of Preparation: June 2019
Brief report: length of ileal resection correlates with severity of bile acid malabsorption in Crohn’s disease
In patients with Crohn’s disease who had a prior surgical resection there was a modest correlation between the length of ileal resection and the severity of bile acid malabsorption (BAM), as defined by tauroselcholic (75selenium) acid (SeHCAT) retention values. Response to bile salt sequestrant therapy was not dependent on SeHCAT retention values.
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