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A source for healthcare professionals to access the latest data and information on the diagnosis, treatment and management of patients with gut related disorders
Professor Julian R.F. Walters
Consultant Gastroenterologist and Professor of Gastroenterology, Imperial College London, London, UK
What, in your opinion, are the primary or underlying mechanisms of bile acid diarrhoea?
Bile acid diarrhoea (BAD) can be caused by any problem that increases bile acids in the colon. This can be due to malabsorption when the ileus does not function correctly, such as in Crohn’s disease.
Another way that BAD can be caused is by an overproduction of bile acids. A deficit in FGF19, a hormone that controls bile acid synthesis, is found in these patients. These bile acids are not absorbed and their excess in the colon causes diarrhoea.
Job number: JB57410GBl Date of Preparation: June 2019
Brief report: length of ileal resection correlates with severity of bile acid malabsorption in Crohn’s disease
In patients with Crohn’s disease who had a prior surgical resection there was a modest correlation between the length of ileal resection and the severity of bile acid malabsorption (BAM), as defined by tauroselcholic (75selenium) acid (SeHCAT) retention values. Response to bile salt sequestrant therapy was not dependent on SeHCAT retention values.
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