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A source for healthcare professionals to access the latest data and information on the diagnosis, treatment and management of patients with gut related disorders
Professor Julian R.F. Walters
Consultant Gastroenterologist and Professor of Gastroenterology, Imperial College London, London, UK
Are the current treatments for bile acid diarrhoea (BAD) effective, and is it likely that in the future there will be better treatments for BAD?
Current therapies, such as colestyramine and colesevelam, bind and eliminate bile acids from the colon. These drugs prevent the excess bile acids causing watery faeces.
Further evidence suggests that the primary defect is due to excess bile acid production, caused by reduced production of FGF19. Therapy to stimulate FGF19, thereby reducing excess bile acids, has been shown in a proof-of-concept study to improve patients’ symptoms.
Job number: JB57410GBl Date of Preparation: June 2019
Brief report: length of ileal resection correlates with severity of bile acid malabsorption in Crohn’s disease
In patients with Crohn’s disease who had a prior surgical resection there was a modest correlation between the length of ileal resection and the severity of bile acid malabsorption (BAM), as defined by tauroselcholic (75selenium) acid (SeHCAT) retention values. Response to bile salt sequestrant therapy was not dependent on SeHCAT retention values.
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