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A source for healthcare professionals to access the latest data and information on the diagnosis, treatment and management of patients with gut related disorders
Professor David S. Sanders
Consultant Gastroenterologist and Professor, Royal Hallamshire Hospital and the University of Sheffield, Sheffield, UK
What is the overall benefit for clinicians of an early diagnosis of bile acid diarrhoea?
The benefit is quite significant, both for the physician and for the patient. For physicians, it provides the possibility to avoid numerous diagnostic tests. For example, when investigating patients with unselected irritable bowel syndrome-type symptoms the chances of successfully diagnosing a disease through colonoscopy are very low.
Nowadays, however, if the tauroselcholic (75selenium) acid (SEHCAT) test is performed first (obviously in conjunction with other accepted tests) I believe that bile acid diarrhoea also known as bile acid malabsorption, could be diagnosed in 1 in every 4 patients. For patients, this can drastically change their journey and experience.
Firstly, there will be no delay in the diagnosis, which in some cases can be up to 6 months, and secondly, colonoscopy can sometimes be avoided.
Job number: JB57410GBm Date of Preparation: June 2019
Brief report: length of ileal resection correlates with severity of bile acid malabsorption in Crohn’s disease
In patients with Crohn’s disease who had a prior surgical resection there was a modest correlation between the length of ileal resection and the severity of bile acid malabsorption (BAM), as defined by tauroselcholic (75selenium) acid (SeHCAT) retention values. Response to bile salt sequestrant therapy was not dependent on SeHCAT retention values.
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