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A source for healthcare professionals to access the latest data and information on the diagnosis, treatment and management of patients with gut related disorders
Sainsbury A, Sanders D & Ford A. Clin Gastroenterol Hepatol 2013;11:359–365.
A high proportion of patients with coeliac disease (CD) experience symptoms similar to irritable bowel syndrome (IBS).
Using data from cross-sectional surveys and case-control studies, the pooled prevalence of symptoms meeting the criteria for IBS in all patients with CD was 38% (95% CI, 27.0%–50.0%). Prevalence in individual studies varied from 20.0% to 58.4%, with statistically significant heterogeneity between studies (p<0.001).
Using data from case-control studies, including 626 patients with CD and 1,995 controls without CD, the pooled odds ratio (OR) for IBS-type symptoms was signiﬁcantly higher in those with patients with CD compared with controls (5.60; 95% CI, 3.23–9.70). All studies included in the meta-analysis included adherence to a gluten-free diet (GFD); adherence ranged from 62% to 100%. The pooled odds ratio for IBS-type symptoms in patients that were non-adherent to a GFD was 2.69 (95% CI, 0.75–9.56).
The pooled OR for IBS-type symptoms in CD patients adherent to a GFD, compared with controls without CD, was 4.28 (95% CI, 1.56–11.75). The pooled OR for symptoms compatible with IBS among CD patients nonadherent to a GFD, compared with controls without CD, was 12.42 (95% CI, 6.84–22.6).
IBS-type symptoms impact the quality of life of patients with CD and symptoms may improve by adopting a GFD. Additional work is required to increase the awareness among clinicians of the high prevalence of IBS-type symptoms in CD, which could lead to improvements in care and quality of life for patients with CD.
Job number: JB57410GBr Date of Preparation: June 2019
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Brief report: length of ileal resection correlates with severity of bile acid malabsorption in Crohn’s disease
In patients with Crohn’s disease who had a prior surgical resection there was a modest correlation between the length of ileal resection and the severity of bile acid malabsorption (BAM), as defined by tauroselcholic (75selenium) acid (SeHCAT) retention values. Response to bile salt sequestrant therapy was not dependent on SeHCAT retention values.
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