BAD

Challenging current views on bile acid diarrhoea and malabsorption

Kurien M et al. Frontline Gastroenterology 2018;9:92–97.

Short summary

Guidance for the use of tauroselcholic (75selenium) acid (SeHCAT) for the investigation of diarrhoea due to bile acid malabsorption (BAM) in patients with diarrhoea-predominant irritable bowel syndrome (IBS-D) and or Crohn’s disease without ileal resection is outlined in diagnostics guidance 7 (DG7). A review of DG7 in 2012 by the National Institute for Health and Care Excellence (NICE) determined that SeHCAT should be recommended for research purposes only. This study describes relevant information made available since this review and investigates the economic consequences of misdiagnosis or inefficient treatment of bile acid diarrhoea (BAD) and BAM.

BAD/BAM affects approximately 1% of the UK population and is frequently misdiagnosed as IBS-D, not considering patients that may be affected by BAM/BAD resultant from secondary causes. Diagnosis of BAD/BAM is often not considered conclusive and as such is not treated effectively. SeHCAT is a specific diagnostic test, licensed for the investigation of BAD/BAM, which has shown high diagnostic value. While NICE recognised that SeHCAT testing was a valuable diagnostic...

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Job number: JB57410GBo(1) Date of Preparation: June 2020

Search Tags
bile acid diarrhoea malabsorption sehcat diarrhoea-predominant irritable bowel syndrome (ibs-d) british society of gastroenterology (bsg) reduce costs nice model dg7 tauroselcholic (75selenium) acid

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