High prevalence of idiopathic bile acid diarrhoea among patients with diarrhoea-predominant irritable bowel syndrome based on Rome III criteria

Aziz, I, Mumtaz S, Bholah H et al. Clin Gastroenterol Hepatol 2015;13:1650–1655.

Short summary

Nearly 25% of patients presenting with diarrhoea-predominant irritable bowel syndrome (IBS-D) have mild to moderate idiopathic bile acid diarrhea (BAD), according to this UK-based study. The severity of BAD in these patients was associated with impaired physical activity. 

This was a prospective dual-centre study involving adults who fulfilled the Rome III criteria for IBS-D. Patients with known risk factors for BAD were excluded from the study. The study included 118 individuals with a mean age of 41.7 years. The total prevalence of BAD was 23.7% (n=28) using a tauroselcholic (75selenium) acid SeHCAT retention score of less than 15% to define the presence of BAD. The prevalence was statistically similar across both...

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Job number: JB57410GBx(1) Date of Preparation: June 2020

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diopathic bile acid diarrhoea rome iii criteria diarrhoea-predominant irritable bowel syndrome (ibs-d) bile acid diarrhea (bad) sehcat

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How common is bile acid diarrhoea (BAD)?
Professor David S. Sanders 

How common is bile acid diarrhoea (BAD)?
Professor David S. Sanders 

Professor Sanders argues that many patients presenting with irritable bowel syndrome (IBS) have underlying diseases. He explores a series of studies that suggest approximately 25% of patients presenting with IBS symptoms have BAD as the underlying cause. 

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