IBD

Inflammatory bowel disease: clinical aspects and treatments

Fakhoury M et al. J Inflamm Res 2014;7:113–120.

Short summary

Inflammatory bowel disease (IBD) is a chronic disease for which there is no cure. This review describes the types and symptoms of IBD, the role of cytokines in the inflammation process and the diagnostic and treatment options.

Patients affected by IBD, primarily Crohn’s disease and ulcerative colitis, often have defects in the intestinal epithelial barrier function and experience abdominal symptoms, including diarrhoea, abdominal pain, bloody stools and vomiting. Although Crohn’s disease and ulcerative colitis are similar, Crohn’s disease can affect any point along the wall of the digestive tract, while ulcerative colitis is localised to the colon. Differential diagnosis is difficult as symptoms are similar.

There are several techniques and tests to aid the diagnosis of IBD, including capsule endoscopy, medical imaging using barium follow-through procedures, X-ray computed tomography and magnetic resonance. Levels of serological markers may aid diagnosis of IBD and help differentiate between Crohn’s disease and ulcerative colitis. Biopsy of the colon is a very effective method to confirm disease and differentiate the type of inflammation based on its intestinal pathology and pattern.

IBDs are associated with defects in the epithelial barrier, which increases the permeability of the intestine and adherence of toxins to intestinal cells. This...

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Job number: JB57410GBp(1) Date of Preparation: June 2020

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inflammatory bowel disease (ibd) symptoms of ibd cytokines crohn’s disease ulcerative colitis diarrhoea abdominal pain bloody stools and vomiting. ulcerative colitis capsule endoscopy medical imaging barium tomography magnetic resonance serological markers epithelial barrier monoclonal antibodies infliximab thalidomide proinflammatory cytokines

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Inflammatory bowel disease (IBD) patient information sheet (English)

Inflammatory bowel disease (IBD) patient information sheet (English)

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