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gutNEWS.org

A source for healthcare professionals to access the latest data and information on the diagnosis, treatment and management of patients with gut related disorders

Patient Support

A resource for gastroenterologists including a series of patient information sheets that can be e-mailed to, or printed out for patients.

What is bile acid diarrhoea?

BAD is a type of chronic diarrhoea, caused by excess bile acids reaching the colon. It can be a very painful and debilitating condition causing numerous episodes of watery and urgent bowel motions sometimes resulting in faecal accidents.

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What is irritable bowel disease?

Inflammatory bowel disease (IBD) refers to a group of disorders that cause chronic swelling and longterm inflammation of the digestive tract or gut.

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What is irritable bowel syndrome?

Irritable bowel syndrome (IBS) is a common disorder of the colon which results in chronic, painful spasms. It can also cause bloating and either constipation or diahorrea, or sometimes both.

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GutNews.org focuses on three key areas of interest:

IBS-D BAD IBD

Bile acid disease: the emerging epidemic 

Oduyebo I & Camilleri M. Curr Opin Gastroenterol 2017;33:189–195.

Type 2 (primary) bile acid diarrhoea (BAD) is associated with increased bile acid production and occurs in nearly 30% of patients with diarrhoea-predominant irritable bowel syndrome (IBS-D). Primary BAD is associated with disorders of serum fibroblast growth factor 19 (FGF-19) which results in excess bile acid synthesis by hepatocytes. This leads to higher concentrations of bile acids in the colon and increased faecal bile acid loss.

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