A source for healthcare professionals to access the latest data and information on the diagnosis, treatment and management of patients with gut related disorders
What is bile acid diarrhoea?
BAD is a type of chronic diarrhoea, caused by excess bile acids reaching the colon. It can be a very painful and debilitating condition causing numerous episodes of watery and urgent bowel motions sometimes resulting in faecal accidents.
What is irritable bowel disease?
Inflammatory bowel disease (IBD) refers to a group of disorders that cause chronic swelling and longterm inflammation of the digestive tract or gut.
What is irritable bowel syndrome?
Irritable bowel syndrome (IBS) is a common disorder of the colon which results in chronic, painful spasms. It can also cause bloating and either constipation or diahorrea, or sometimes both.
GutNews.org focuses on three key areas of interest:
Bile acid disease: the emerging epidemic
Type 2 (primary) bile acid diarrhoea (BAD) is associated with increased bile acid production and occurs in nearly 30% of patients with diarrhoea-predominant irritable bowel syndrome (IBS-D). Primary BAD is associated with disorders of serum fibroblast growth factor 19 (FGF-19) which results in excess bile acid synthesis by hepatocytes. This leads to higher concentrations of bile acids in the colon and increased faecal bile acid loss.
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